Inhibition of Nuclear Import of Calcineurin Prevents Myocardial Hypertrophy
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چکیده
منابع مشابه
Inhibition of nuclear import of calcineurin prevents myocardial hypertrophy.
The time that transcription factors remain nuclear is a major determinant for transcriptional activity. It has recently been demonstrated that the phosphatase calcineurin is translocated to the nucleus with the transcription factor nuclear factor of activated T cells (NF-AT). This study identifies a nuclear localization sequence (NLS) and a nuclear export signal (NES) in the sequence of calcine...
متن کاملTargeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy.
Cardiac hypertrophy is a major predictor of future morbidity and mortality. Recent investigation has centered around identifying the molecular signaling pathways that regulate cardiac myocyte reactivity with the goal of modulating pathologic hypertrophic programs. One potential regulator of cardiomyocyte hypertrophy is the calcium-sensitive phosphatase calcineurin. We show here that calcineurin...
متن کاملDirected inhibition of nuclear import in cellular hypertrophy.
Each nuclear pore is responsible for both nuclear import and export with a finite capacity for bidirectional transport across the nuclear envelope. It remains poorly understood how the nuclear transport pathway responds to increased demands for nucleocytoplasmic communication. A case in point is cellular hypertrophy in which increased amounts of genetic material need to be transported from the ...
متن کاملCalcineurin signalling mechanisms in myocardial hypertrophy
Calcineurin dephosphorylates multiple serine residues near the N terminus of NFAT proteins enabling them to translocate from cytoplasm to nucleus, where they activate a subset of hypertrophic response genes. Transgenic mice over-expressing a constitutively active form of calcineurin or NFAT3, developed obviously hypertrophy and heart failure or sudden death proving its pathogenic role. Here we ...
متن کاملSignaling in myocardial hypertrophy: life after calcineurin?
Signaling in Myocardial Hypertrophy : Life After Calcineurin? Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.84.6.633 1999;84:633-646 Circ Res. http://circres.ahajournals.org/content/84/6/633 World...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2006
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000243208.59795.d8